哺乳動物細胞尋覓營養的策略

信息來源:
http://www.natureasia.com/zh-cn/nature/highlights/86332
https://www.nature.com/nature/journal/v546/n7657/full/nature22379.html

哺乳動物細胞會選擇性地從周圍環境中吸收營養,以滿足自身的各種需求,如增強代謝穩定性以抵御饑餓。Wilhem Palm和Craig Thompson綜述了我們對哺乳動物細胞感知和獲取營養策略的認識。養分平衡是內穩態和細胞增殖的一個關鍵特征,因此,作者探討了轉化細胞是如何利用這些代謝途徑來促進癌細胞生存和生長的。

Nutrient acquisition strategies of mammalian cells

Wilhelm Palm & Craig B. Thompson

Nature 546, 234–242 (08 June 2017) doi:10.1038/nature22379

Mammalian cells are surrounded by diverse nutrients, such as glucose, amino acids, various macromolecules and micronutrients, which they can import through transmembrane transporters and endolysosomal pathways. By using different nutrient sources, cells gain metabolic flexibility to survive periods of starvation. Quiescent cells take up sufficient nutrients to sustain homeostasis. However, proliferating cells depend on growth-factor-induced increases in nutrient uptake to support biomass formation. Here, we review cellular nutrient acquisition strategies and their regulation by growth factors and cell-intrinsic nutrient sensors. We also discuss how oncogenes and tumour suppressors promote nutrient uptake and thereby support the survival and growth of cancer cells.
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